The effect of necrosis and tumor on the cell kinetics of small bowel.

Generation time and S phase time of the jejunum in the normal golden hamster were estimated by the autoradiographic technic with thymidine-3H. These times were compared with the genera tion and S phase times of a group of hamsters with transplanted fibrosarcomas and a group with turpentine abscesses. The generation time was shorter in animals with necrotic lesions. It is suggested that the common factor of tissue necrosis in both inflammatory lesions and tumors causes acceleration of cell turn over in other regenerating tissues; or, both tissue necrosis and neoplasia can produce this effect. This generalized increased synthesis of tissue may contribute to the cachectic state.